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A Functional Understanding of CBD



As many have come to understand, CBD has various medical uses, and is presently being utilized by an extraordinary huge number of individuals from all levels of society worldwide, each one treating a specific medical condition or health issue.

Below, we will embark on a detailed investigation into How CBD Really Works. We hope you find this both interesting and educational as you move to ascertain how CBD can be of service in your life as a preventative, treatment, and supplement, as so many others have already found.

Cannabidiol (CBD)

Cannabidiol (CBD) is one of the most prominent active compounds in hemp and cannabis. It is differentiated from THC by virtue of the fact that it does not create the same type of drug experience – the “high” – that THC creates. The explanation behind this distinction between the two substances is the way that, while THC straightforwardly collaborates with the CB1 and CB2 receptors in the body, CBD takes after a fairly roundabout approach towards the same receptors, impacting their functioning without completely binding.

Here is the big point: you have cannabinoids in your body all the time. Your body makes them. CBD helps your body use its own cannabinoids more effectively and efficiently.

The Endocannabinoid System and CBD

Sensations in the psyche and physiology are being controlled by cannabinoid receptors.

These are intended to associate with Cannabinoids created in the body. Some examples of sensations under the purview of these receptor reactions include: hunger, state of mind, pain, sensation, and memory. These receptors are fundamentally isolated into two noteworthy classifications named as CB1 and CB2.

While intended to communicate with the regular Endocannabinoids which are normally delivered by the brain inside the human body, they can also react with phyto-cannabinoids like THC and CBD, and others.

The Key Receptors: CB1 and CB2

Both CB1 and CB2 receptors play key roles in regulating the body’s physiology on many levels. While CB2 is a key part of the immune system, CB1 is regularly part of the nervous system and to some extent may likewise be a piece of the kidneys, lungs, or liver. A couple of the normal capacities satisfied by the CB1 receptor incorporate the arrival of neurotransmitters.

These neurotransmitters come in many forms and control much of what and how we feel as brain-owners. However, they are also known to deliver the psychoactive impact that we feel when experiencing the high associated with THC.


CBD and THC differ greatly in terms of both their mode of action in the body and the impact they have on us.

THC is the one that delivers the “high” most associate with smoking pot or otherwise consuming cannabis on a recreational level. And it binds directly with the receptors involved in the endocannabinoid system of the body.

CBD, by contrast, is more involved in prevention, maintenance, and treatment of health. It does not contain any psychoactive properties (ie, does not deliver that same drug “high”), and also does not bind directly with the ECS receptor system.

The method of activity of CBD is varies quite a bit from that of THC as in it isn’t engaged with coordinate incitement of the previously mentioned receptors. The essential effect of CBD is caused on different receptors, for example, Serotonin, Adenosine, and Vanilloid.

For example, the incitement of TRPV-1 receptor by CBD intercedes an assortment of procedures including inflammation, body temperature, and pain recognition. In addition, CBD is known to cause a restraint in the working of FAAH enzyme that straightforwardly follows up on the CB1 receptor and empowers THC to create its psychoactive impact.

Here are several key therapeutic applications:

Anti-anxiety and Anti-Inflammatory Properties. The anti-anxiety or anti-inflammatory effect of CBD is for the most part connected with the actuation of Adenosine receptor. By fortifying adenosine, CBD advances the arrival of dopamine and glutamate neurotransmitters. Procedures like motor control, perception, inspiration, and reward system are related to the arrival of dopamine, while glutamate is engaged with learning, memory arrangement, excitatory signs, and discernment.

CBD and Serotonin. However, these are not every one of the capacities that are satisfied by CBD inside the human body. It is additionally engaged with the incitement of 5-HT1A serotonin receptor that is known to deliver the anti-depressant impact. This receptor is normal to a tremendous scope of different procedures, for example, craving, pain discernment, sickness, anxiety, and fixation systems. Last yet not the slightest, it has additionally been discovered that CBD tends to decrease the expansion of the cancerous cells and bone reabsorption by means of restraint of GPR55 flagging. GPR55 is prevailing inside the brain and has been related with the indispensable procedures like controlling the circulatory strain, tweaking the bone thickness, and keeping the expansion of cancerous cells.

PPARs – atomic receptor. CBD likewise shows as an anti-cancer treatment by actuating PPARs, otherwise called peroxisome proliferator initiated receptors, which are found on the surface of the phone’s core. Initiation of a receptor alluded to as known as PPAR-gamma has a capacity to actuate the relapse of tumors in human lung cancer cell lines. By enacting PPAR-gamma amyloid-beta plaque, which is a key molecule connected to the improvement of Alzheimer’s disease is corrupted. Along these lines, Cannabidiol, might be a valuable solution for treating Alzheimer’s in patients. Qualities that impact procedures, for example, vitality homeostasis, lipid take-up, insulin affectability, and other metabolic capacities are additionally managed by PPAR receptors. For the reason, diabetics may profit by connecting with into CBD-rich treatment.

Inhibiting Reuptake with CBD

Cannabinoids penetrate the cell membrane by attaching to a Fatty Acid Binding Protein. This protein comes with the package in certain lipid molecules. These intracellular molecules also transport Tetrahydrocannabinol (THC) and the brain’s own particular cannabinoids.

These include the Endocannabinoids Anandamide and 2AG. They head to their particular destinations inside the cell. CBD and THC both control receptors on the surface of the mitochondria and also the core of the cell.

Cannabidiol is firmly drawn to three sorts of FABPs, and it additionally battles with our Endocannabinoids, which are unsaturated fats, for a similar transport molecules. Once inside the cell, Anandamide is separated by FAAH (unsaturated fat amide hydrolase) which is a metabolic enzyme.

FAAH is a characteristic piece of the cell’s sub-atomic life cycle. Be that as it may, CBD meddles with this procedure by lessening Anandamide’s entrance to FABP transport molecules, in this way postponing Endocannabinoid’s entrance into the cell.

How Can CBD Work for You?

Research has shown that it is possible to impact the functioning of the ECS, and such a form of treatment has the potential to aid in combating many health issues.

Will such a course of treatment induce a psychoactive “high”?

No. In fact, research has clearly established that proper dosage and administration can produce the desired effects without any such psychoactive consequences. Importantly, not all of the cannabinoids derived from cannabis induce that type of high.

Hence, these compounds have become an intense area of study as potential major treatment solutions for a long list of ailments, including anxiety disorders, mood disorders, Parkinson’s, Huntington’s, multiple sclerosis, neuropathic pain, spinal cord injury, cancer, atherosclerosis, myocardial infarction, hypertension, stroke, glaucoma, osteoporosis, and many more.

There are various ways to consume CBD, include vape oil, tinctures, capsules, ingestible oil, edibles, and topical creams and sprays.

It takes time and experimentation to figure out what’s right for you. But on this site, you will find much helpful information to guide through that process of trial and error and lead you in the right direction so that CBD can be as helpful in maintenance, therapy, and prevention as it has been for so many other millions around the world.

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The Effects of CBD and Glaucoma



facts about CBD and Glaucoma

As we discussed the variety of different health conditions that appear to be treatable or preventable through the use of CBD, we must admit to the existence of a spectrum of efficacy. In other words while it appears to have an enormous range of application, there are certain things that it works even better for than others.

One of the best of the bunch is glaucoma.

As the reader is likely aware, glaucoma is a defect with implications for severe damage to an individual’s optic nerve, and thus a failure in the proper functionality of the eye.

Coming to Terms with Glaucoma

While we don’t understand exactly how it’s cause, the most relevant source of serious long-term damage to the optic nerve in cases of glaucoma appears to be hypertension on an intraocular level. In other words,, comes from too much pressure inside of the eye because of too much fluid in between the iris and cornea.

How prevalent is glaucoma? About 2 million suffer from it just in the US. Most of them are around 50 years of age or older by the time we actually see signs of the glaucoma.

The early stage symptomology is relatively inconspicuous. The first thing you deal with in a case of glaucoma’s difficulty seeing out to your periphery – otherwise known as a loss of peripheral vision. If this happens to you, unfortunately I have some bad news: glaucoma is already irreversible at this stage.

This is when we know that there’s already too much pressure directly in the eye and damage is already been done to the optic nerve.

While we don’t fully understand exactly why or how this happens from the outset, the consequences are undeniable.

Here’s how it breaks down: the eye produces something called aqueous humor. No, that’s not a comedy club for fish. It’s actually a fluid it’s meant to sit between the iris and cornea of the eye. But when there’s too much of it, it results in pressure that can damage the optic nerve. It’s also important to understand that this is a very sensitive system.

The optic nerve is actually a highly delicate grouping of nerve tissue and it’s easily damaged. It is a highly delicate instrument. Any alteration leads to irreversible issues with vision.

Can CBD Help?

As we have described, glaucoma is the result of a failure to regulate some delicate balance of some kind of substance somewhere in the body – in this case, the aqueous humor in the eye. What we want to highlight here is that this is a regulatory issue.

While CBD is still on the frontier of its important research development, one thing we have learned for certain at this point is this: CBD is great at regulatory problems.

Why? Because CBD impacts the endocannabinoid system, and the endocannabinoid system is intimately tied into most of the body’s major regulatory systems.

That’s why it’s so good at helping with immune system issues, inflammation issues, pain management, and hormonal balance. These are all important regulatory functions in the body, and ones that the endocannabinoid system is intimately integrated within.

As such, anecdotal and formal research has shown CBD could be a highly valuable tool in the battle against glaucoma. While more research needs to be conducted, we already know that it’s effective, and we already have a pretty good idea why.

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Treatment Option for CBD and Sickle Cell Anemia



Did you know that scientists aren’t even sure how many people are affected by sickle cell anemia in the world right now? Most people don’t realize that one of the most frequently identified hereditary conditions is in fact sickle cell anemia.

While we don’t know exactly how many people suffer from this difficult condition, we do know that it’s at least millions. Those living in Southwest Asia, the Mediterranean countries, Africa, and India are most at risk.

Coming to Grips with Sickle Cell Anemia

Sickle cell anemia is a common version of the sickle cell disease, as you might guess. The most important and peculiar characteristic that defines this disease is a crescent shape found in red blood cells.

A red blood cell isn’t supposed to be crescent-shaped. Instead, it supposed to be round and flattish, allowing transportation through membranes with tight gaps, which are common throughout the body’s circulatory system.

It is this crescent-shaped or sickle shaped character as well as a rigidity that is responsible for all of the problems that go along with sickle cell disease.

What Causes Sickle Cell Disease?

The cause of sickle cell disease is a gene mutation. Specifically, it is the gene that responsible for hemoglobin production.

Hemoglobin, an important protein found in red blood cells, attaches itself to oxygen molecules to help transport them around the body.

The mutation that causes sickle cell disease is a mutation involved in the production of the shape of red blood cells, resulting in the misshapen, rigid, sickle shaped design that is responsible for the problems that come with this difficult condition.

At the end of the day, the problem that is found with this condition is that of factors involved in causing a difficulty adjusting when the weather is cold, some occasional bouts of dizziness, and a lack of energy.

Diagnosis is actually extremely easy, and most cases of the disease are already detected by the time the baby is born. That said, to know for sure, a doctor will prescribe a blood test diagnosis that will determine precisely whether or not the patient carries the sickle cell abnormality and thus will suffer from effects associated with the disease.

A Solution and a Problem

If you understand more about sickle cell disease, it may not be too surprising to know that case density is greatest in areas where prevalence of malaria is to be found.

You see, the odd shape of red blood cells for individuals with sickle cell disease actually works to repel the spread of malaria throughout the body. Hence, over an even illusionary timeline, sickle cell disease has actually evolved as a defense in areas where malaria is particularly common in individuals are likely to be exposed to it.

In such places, having sickle cell disease actually decreases one’s chances of death, thereby increasing one’s chances of survival and eventual reproduction. This is why the disease has gained traction in certain areas of the world.

How Can CBD Help?

While there are no absolute treatments for sickle cell disease, cannabis and CBD have appeared to make a positive difference in both coping and managing the process that one must endure as a sufferer of sickle cell anemia.

CBD works to aid in the functionality of the immune system as well is the nervous system, thus treating many of the symptoms that are most often experienced by those with this terrible disease.

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Important New Tool CBD Migraines




There can be no doubt about it: headaches are a real headache. For those that suffer from migraines, headaches can be hell.

It’s important for people to understand that migraines represent a special form of headache that constitutes a major health problem. Migraine headaches can be so severe that they can bring about suicidal thoughts for those who suffer from them chronically. But, for such unfortunate individuals, we do have some good news: there is a new weapon in the fight against migraine headaches – CBD.

Migraines, and the Search for a Cure

Any attempt to fully understand the migraine health issue and it’s possible treatment options must start with the following fact: migraine headaches have no known cure.

Certainly, there are many treatments out there that claim to provide some relief for a chronic migraine headache problem. But none have been shown to truly stop the problem from being a part of life for those who suffer from this terrible condition.

Some of the tools offered to us by the pharmaceutical industry to treat migraine headaches include trazodone, propranolol, L-5HTP, flunarizine, nimodipine, and papaverine. However, once again, none represents a cure, and many have important and life-changing side effects included in the package.

However, the good news is that CBD has begun to offer a new ray of hope in this battle. Recent research suggests a strong potential for cannabis and cannabis related substances to provide important measures of relief for those suffering chronically for migraine headaches.

For example, recent research in the journal ‘Pharmacotherapy’ suggests that scientists are starting to build the case that the frequency and intensity of headaches for chronic migraine sufferers can be powerfully impacted by CBD.

Survey Evidence Could Point the Way

In addition, other studies can also be of important note. Unfortunately, one important study did not particularly isolate CBD but may still help to make the case for the impact that CBD can have as a tool for those suffering from this difficult condition.

In fact, in this case, it is an important survey. Assembled by SFGate, the survey was comprehensive and stated clearly that 100% of individuals who responded stated that CBD oil sharply diminished the intensity and frequency of their headaches.

As you may be aware, CBD is perhaps the most important of the cannabinoids, and has zero psychoactive impact. According to historical research, use of CBD for headaches dates back to the Roman Empire, over 2000 years ago.

There is firm evidence to suggest that CBD represents a valuable tool in the fight against migraine headaches. More research is needed to confirm this hypothesis in a manner that is sufficiently convincing for the medical and scientific establishment. But for patients and consumers in the world today suffering from this terrible condition, know that history and anecdotal evidence makes one crystal clear case: that CBD is a tool with tremendous potency and promise.

One should expect the drift of research to land on the same conclusion over time.

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