Cannabinoids, as we have covered, are remarkable compounds widely found in the cannabis plant. And, while these extraordinary substances have enormously helpful interactions with the endocannabinoid system found in mammals, it’s important to develop an understanding of the variety that exists where this class of compound is concerned.
What are Cannabinoids?
As most readers probably already know, THC is the most well-known cannabinoid in the family. And these substances aren’t just important to our health, but actually drive the health of the cannabis plant as well. These sticky substances actually work to protect the plant from pathogens and creepy crawly critters.
In addition, cannabinoids exude a strong odor that actually functions to repel certain species of insects, which could otherwise damage the cannabis plant. They also work to drive away bacteria and potentially harmful fungus invaders.
Importantly, as we will cover below, each cannabinoid comes in two different forms: an acid and a neutral. The acid form is the one that is actually produced by the cannabis plant. It is through exposure to air, light, and different levels of heat that the acid form degrades into the neutral form, which is far more potent for our needs, and hence quite convenient.
THC is the granddaddy of the group. Aside from being the most abundant of all cannabinoids, it is also the only one that directly interacts with the CB1 receptor in the endocannabinoid system. It is that interaction that produces the familiar “stoned” feeling that we so often associate with marijuana. THC also works to inhibit inflammation, which includes the production of cytokines known as prostaglandins. Finally, THC reduces the excitability of neurons, which has made it quite useful in combating epilepsy.
First off, note that this cannabinoid’s name ends with an interesting suffix. The presence of the “-varin” part of the word connotes a curtailing of the carbon sidechain by two atoms in the molecular form. In addition, this cannabinoid increases the concentration of an important inhibitory neurotransmitter, thus amplifying several traditional epilepsy medications.
Some research suggests that this substance actually functions to inhibit phases of the cell cycle. This may impact tumor growth rates. It also works to amplify the impact of other cannabinoids on aspects of the human nervous system, particularly in sensation.
Tetrahydrocannabinolic acid (THCA)
This is the closely-related acid cousin of THC, and is the most abundant cannabinoid on the planet. The reason for this is quite simple: humans wanted it that way. And through generations and generations of selective breeding, we have shaped the world as we most like it. This substance also functions to strongly inhibit the effect of TNF-a, which is a chemical that is part of the immune system and is operative in the developmental paths of many autoimmune disorders. As described above, this substance becomes the more familiar THC after it is heated or dried.
This is absolutely identical to THC, except as we discussed above for a shortened sidechain of carbon atoms. Interestingly enough, it functions to counter the psychoactive effects of THC due to its presence as an antagonist of the CB1 receptor in the endocannabinoid system.
Cannabidiol is also one of the most abundant cannabinoids, as another testament to the wishes of farmers. Naturally, as we have noted, it interacts strongly with the receptors of the endocannabinoid system, generally amplifying the functionality of the system as a whole. Research also suggests that it activates some serotonin receptors, which allows it to decrease fear and anxiety felt by the consumer. In addition, cannabidiol is a potent antioxidant that also functions to activate aspects of human DNA that may have application in fighting tumors.
This one is known for its ability to inhibit, or prevent, the active impact of a couple of important pain stimulating receptors in the nervous system. We can all imagine how helpful that might be at times. In addition, it reduces excessive glandular activity, including those that lubricate the dermis.
Cannabidiolic Acid (CBDA)
As with THCA, this one is identical in character to CBD, except it is the acidic form found in the cannabis plant. It becomes standard neutral CBD when heated or exposed to light and air.
CBG is an interesting one. It actually prevents reuptake of GABA, which functions as an inhibitory factor in the synaptic gaps in the brain. It also counters the psychoactive effects of THC by antagonizing the endocannabinoid receptors.
Cannabigerolic acid (CBGA)
Scientists have found that CBGA is actually the original cannabinoid – an evolutionary precursor to all the rest. It doesn’t present in high volume because it morphs into the other forms as the plant matures.
Vapor Group Inc (OTCMKTS:VPOR) Business Model Paying Off As Orders for Isolate CBD Stream In
Vapor Group Inc (OTCMKTS:VPOR) is evidently having a spectacular run following the adoption of a new business model early this year focused on the lucrative CBD industry estimated to be worth well over $16 billion. The company recently secured $80,000 order for its premium CBD isolate bringing the total tally of orders to $600,000 this year alone.
$500,000 in under 3 months
As of April this year, the company had reportedly secured orders totaling about $500,000. In its Q1 2019 earnings, VPOR reported a number of high-profile business deals from reputable names in the industry including White Label liquid and GenCanna global, Inc among others. The company’s biggest purchase order thus far came in May when industry titan, Diamond CBD owned by potNetwork holdings placed a hefty $210,000 order for its bulk CBD isolate.
Vapor bills itself as the provider of industry grade CBD isolate famed for its high potency and purity. The product is developed in the company’s state-of-art manufacturing facilities that utilize sophisticated nanotechnology to deliver a premium end product sought after by industry leaders. The trickling enormous purchase orders are testimony of the product’s unparalleled effectiveness.
The company’s products are manufactured from 100% organic hemp sourced from the best growers in the United States from the states of Colorado, Kentucky, and Oregon. VPOR is constantly researching and experimenting on new processing methods and techniques to stay at par with the industry’s dynamic trends.
VPOR’s President and CEO, David Zinger is confident that the company is on course to becoming the premium suppliers of industry-level CBD isolate. Zinger credits the company’s success to over the past few months to “smart planning and strategizing.” Further, he is optimistic that with the continued sustainable growth, the will be able to provide long-term value to their stakeholders.
Positive trends witnessed in the CBD industry points to a lucrative future for players in the sector including Vapor. Reportedly, 7% of Americans are using CBD products now with the number expected to spike by 10% come 2025.
Medical Marijuana Inc. (OTCMKTS:MJNA) Authorized To Offer CBD Products In Bulgaria
Medical Marijuana Inc. (OTCMKTS:MJNA) has announced that it has been granted authorization to sell its hemp derived CBD products in Bulgaria.
Medical Marijuana receives authorization for CBD products in Bulgaria
Blake Schroeder the CEO of Kannaway stated that they are delighted to continue paving the way for CBD acceptance in Bulgaria to follow suit with what is happening in the rest of the world. The CEO added that following the authorization they were hoping to position themselves in the Bulgarian market and become leaders in CBD education across Europe.
The authorization means that Kannaway’s goods will be freely sold in Bulgaria and they are equally approved for export. Kannaway VP Alex Grapov said that the company was looking forward to trailblazing the global CBD market as advocates of its benefits. He added that they have met with regulatory bodies to makes sure that the company’s operations are within the purview of the law thus creating an avenue for customers and brand ambassadors.
Publication of CBD research on CIPN in Molecular Sciences Journal
Last week Medical Marijuana announced that its portfolio company Kannalife Inc. (OTCMKTS: KLFE) had published its findings on Chemotherapy-Induced Peripheral Neuropathy in the Molecular Neuroscience Journal. Market Study Report LLC has indicated that the international market for CIPN treatment is expected to exceed $1.88 billion by 2024. Kannalife expects clinical trials for its CBD-like molecule KLS-13019 as a therapeutic treatment for CIPN to commence in the second quarter of 2020.
Medical Marijuana CEO Stuart Titus said that CIPN affects around 30% to 405 of patients undergoing chemotherapy adding that they were pleased to support Kannalife in its research to discover a treatment alternative for such patients.
Kannalife was funded by the National Institute on Drug Abuse to work on the research. The grant permits the research in the development of KLS-13019 in CIPN and drug dependence. Kannalife has the obligation to study important advancements that involve identification of the mechanisms that bring CIPN and the application o0f study results in designing on novel treatment approaches for neuropathic pain and use of the approaches in reducing opioid prescription and opioid abuse.
Generex Biotechnology Corporation (OTCMKTS:GNBT) Launches An Integrated Health Management Platform
In a new wake of events, Generex Biotechnology Corporation (OTCMKTS:GNBT) has introduced a platform, which primarily deals with in-depth patient health management services. NuGenerex Medical Marketing (NMM) is a significant project and will act as the company’s sales and marketing backbone support. Some of the areas it will handle include patient identification, acquisition, and onboarding. Its establishment comes at a time when hundreds of pharmaceuticals businesses are seeking measures to accelerate their growth and expansion.
Generex is seeking entry into the U.S market and the reason it has embraced a multi-channel acquisition strategy. The strategy has been running for several months the main target being assets and organizations, which offer a series of services.
NMM will provide national marketing and customer service capabilities
Generex will benefit in a million ways from the new establishment; thanks to its capabilities. NMM plans to roll out an extensive pharmacy backbone, which will in return offer a nationwide footprint. It will have an integration with Customer Relationship Management (CRM) dashboard for Generex. Through a dedicated call-center, the integration will support the company’s ongoing patient support services and particularly the chronic care management.
In addition, NMM will offer compliant direct-to-patient outreach services, which are fully compliant with the market needs. An accomplished team, which has deep experience in pharmaceutical and medical device sales will support the new move. The team is trained in HIPAA, FTC and it has full exposure of the FDA rules. Thus it will ensure adherence to processes and procedures in the delivery of medical services.
The realization of a vision for a new healthcare enterprise
For the last two years, Generex has worked diligently to enhance the delivery of its services. Its emphasis is on unlocking new platforms, which will offer end-to-end treatment and services solutions. This far, the company is happy with its achievements according to the Chief Executive Officer Joseph Moscato.
He says, “We are delighted to launch NuGenerex Medical Marketing as another step in our overall corporate strategy to provide end-to-end solutions that optimize patient health outcomes.”
Meanwhile, the company has vowed to continue closing on the acquisition of additional operating assets. Its expectation is to meet the initial listing requirements one of them being a lucrative enterprise with a presence in another 23 states.