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Addisons Disease and CBD Treatments



There is a dysfunction that is quite rare and of completely unknown origin that represents a disorder of the adrenal cortex. It is sometimes called Primary Adrenal Insufficiency, but is more commonly known as Addison’s Disease.

The condition is characterized by unstable mood, potential adrenal crisis, weight loss, general lack of appetite, and fatigue. When adrenal crisis is present, one will often observe a sharp drop in blood pressure accompanied by a state of dizziness, fainting, and pain in the lower half of the body. Such an attack can even be fatal, and emergency services should be contacted immediately.

Understanding Addison’s Disease

As noted above, this is an issue characterized by a dysfunction of the adrenal cortex, which is essentially made of two glandular organs that can be found on the roof of the kidneys in the human body.

All of this really comes down to what is known as the hypothalamic-pituitary-adrenal axis, also known as the HPA. This is essentially the nexus point that connects the human endocrine and central nervous systems.

The endocrine system is basically the regulatory system overseeing hormones and signaling molecules that are in charge of a number of different chemical processes of a regulatory nature in the systematic functionality of mammalian physiology.

The adrenal system is basically a part of this, and is in charge of things like our fight or flight reflex and our ability to ramp up bodily processes to respond to danger, stress, or high emotion situations. The pituitary gland is basically in charge of most of this. It does its work through the production of mineralocorticoids and glucocorticoids.

Addison’s disease is basically about a situation when the adrenal cortex undergoes an autoimmune assault or atrophies for unknown reasons. The net result is that it no longer produces the hormones necessary to allow the regulatory processes of the human body to function properly.

You can imagine why this could be such a problem. We need our regulatory systems in our body to maintain proper functioning of our physiological systems because so much going on in the body depends upon proper levels of different chemicals in any system at any given time. Various bodily systems work together, hand in hand, on so many different levels that a systematic breakdown of any one of these regulatory functions can be nearly or entirely impossible for medical science to treat.

While much of what we do to maintain our health on a daily basis is really about maintaining these systems and preventing problems, sometimes, for certain individuals, such regulatory breakdowns and physiological problems are inevitable, and so some sort of therapy or treatment is necessary.

CBD and Addison’s Disease

While this is a very uncommon disease, it may be tailor-made as an excellent candidate for treatment or therapy involving cannabidiol, or CBD.

As we have discussed at length, the endocannabinoid system is intimately tied into most of the body’s various regulatory functions. Because many cases of Addison’s disease derive in some way from an inflammatory autoimmune problem, CBD may play an important role in solving this dilemma. You see, much of the body’s inflammatory autoimmune reactions are governed by failures of the proper functioning of the endocannabinoid system.

As we have found through much anecdotal evidence and some research, introduction of cannabidiol can restore the proper functional balance of the endocannabinoid system in the human body, thereby allowing it to properly regulate an overly excited inflammatory autoimmune response.

As such, CBD may be excellent in preventing the onset of the more developed phase of Addison’s disease. However, this means it would need to be administered before higher-level symptoms have occurred, which could mean daily application by individuals who don’t even realize that there is risk of contracting this difficult disease.

In addition, CBD may also be able to relieve many of the symptoms, including mood instability, fatigue, vascular issues, and lack of appetite, that are often associated with Addison’s disease.

One enzyme pathway that may be intimately involved in the pathogenesis of this condition is cytochrome P450, or CYP450. One of the specific enzymes on this pathway, 21-hydroxylase, has been found to be involved in over 80% of all Addison’s cases.

As a strong indication of promise, CBD has been shown to block the autoimmune response to this vital enzyme. We don’t know exactly why this seems to work so well, but it’s good to know that it does.


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Healing Properties CBD and Addison’s Disease



Primary adrenal insufficiency, also known as Addison’s disease, is a very rare condition that impacts the adrenal cortex, resulting in a number of very difficult symptoms, including a lack of appetite, lethargy, possible adrenal crisis, loss of weight, and erratic mood.

One of the symptoms noted above – adrenal crisis – is a particularly acute experience that should be treated as a medical emergency. During that adrenal crisis, one may experience a dramatic loss of blood pressure accompanied by dizziness, lower body pain, and fainting spells.

Such an attack can result in death.

Coming to Grips with Addison’s Disease

The adrenal cortex is a rare instance of the word cortex being applied to something that is outside of the brain. In fact, the adrenal cortex is found on the top of the kidneys, and is made of a couple of different glands.

This is part of the HPA, which is an important axis of connected components that regulate many different functions in the body.

One element of this system is known as the endocrine system, which is in charge of various molecular signals in the body, such as hormones. The regulation of this system is critical in a number of different processes that sit at the very core of our physiological functionality.

On the other hand, the adrenal system is in charge of things like our ability to deal with sudden danger – commonly known as the fight or flight system. This is how we respond to highly stressful and highly dangerous situations encountered unexpectedly during daily life. Much of this is dealt with by the pituitary gland, which produces important chemical components that instinctively energize responses in the body.

For those suffering from Addison’s disease, we see it atrophying of this core system. This interrupts the processes that allow us to behave in a manner that our bodies were designed.

Without this properly functioning system we can end up lacking important responses in certain situations while having those responses happen to us in inappropriate situations. But we can also have a number of other symptoms such as those described above.

The role of CBD In Addison’s Disease

It’s certainly true that Addison’s disease is relatively uncommon. However, CBD is an excellent resource for those suffering from this terrible condition.

In our other pieces, we have previously described the importance of the endocannabinoid system and how it is tied throughout the body’s important systems.

Well, as you might have guessed, the endocannabinoid system is also an important part in dealing with Addison’s disease. Because this is such a critical and interconnected system throughout the body, you’ll find that it has a very complex relationships with many different sources of discomfort, malady, and disease. The case of Addison’s disease is no different.

CBD can be an important component in treating and or preventing a case of Addison’s disease because it isn’t impactful element in the functionality of the endocannabinoid system, as we have discussed in our prior pieces. In fact, much anecdotal evidence exists alongside some genuine research by the medical and scientific community to support these contentions.

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The Effects of CBD and Glaucoma



facts about CBD and Glaucoma

As we discussed the variety of different health conditions that appear to be treatable or preventable through the use of CBD, we must admit to the existence of a spectrum of efficacy. In other words while it appears to have an enormous range of application, there are certain things that it works even better for than others.

One of the best of the bunch is glaucoma.

As the reader is likely aware, glaucoma is a defect with implications for severe damage to an individual’s optic nerve, and thus a failure in the proper functionality of the eye.

Coming to Terms with Glaucoma

While we don’t understand exactly how it’s cause, the most relevant source of serious long-term damage to the optic nerve in cases of glaucoma appears to be hypertension on an intraocular level. In other words,, comes from too much pressure inside of the eye because of too much fluid in between the iris and cornea.

How prevalent is glaucoma? About 2 million suffer from it just in the US. Most of them are around 50 years of age or older by the time we actually see signs of the glaucoma.

The early stage symptomology is relatively inconspicuous. The first thing you deal with in a case of glaucoma’s difficulty seeing out to your periphery – otherwise known as a loss of peripheral vision. If this happens to you, unfortunately I have some bad news: glaucoma is already irreversible at this stage.

This is when we know that there’s already too much pressure directly in the eye and damage is already been done to the optic nerve.

While we don’t fully understand exactly why or how this happens from the outset, the consequences are undeniable.

Here’s how it breaks down: the eye produces something called aqueous humor. No, that’s not a comedy club for fish. It’s actually a fluid it’s meant to sit between the iris and cornea of the eye. But when there’s too much of it, it results in pressure that can damage the optic nerve. It’s also important to understand that this is a very sensitive system.

The optic nerve is actually a highly delicate grouping of nerve tissue and it’s easily damaged. It is a highly delicate instrument. Any alteration leads to irreversible issues with vision.

Can CBD Help?

As we have described, glaucoma is the result of a failure to regulate some delicate balance of some kind of substance somewhere in the body – in this case, the aqueous humor in the eye. What we want to highlight here is that this is a regulatory issue.

While CBD is still on the frontier of its important research development, one thing we have learned for certain at this point is this: CBD is great at regulatory problems.

Why? Because CBD impacts the endocannabinoid system, and the endocannabinoid system is intimately tied into most of the body’s major regulatory systems.

That’s why it’s so good at helping with immune system issues, inflammation issues, pain management, and hormonal balance. These are all important regulatory functions in the body, and ones that the endocannabinoid system is intimately integrated within.

As such, anecdotal and formal research has shown CBD could be a highly valuable tool in the battle against glaucoma. While more research needs to be conducted, we already know that it’s effective, and we already have a pretty good idea why.

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Treatment Option for CBD and Sickle Cell Anemia



Did you know that scientists aren’t even sure how many people are affected by sickle cell anemia in the world right now? Most people don’t realize that one of the most frequently identified hereditary conditions is in fact sickle cell anemia.

While we don’t know exactly how many people suffer from this difficult condition, we do know that it’s at least millions. Those living in Southwest Asia, the Mediterranean countries, Africa, and India are most at risk.

Coming to Grips with Sickle Cell Anemia

Sickle cell anemia is a common version of the sickle cell disease, as you might guess. The most important and peculiar characteristic that defines this disease is a crescent shape found in red blood cells.

A red blood cell isn’t supposed to be crescent-shaped. Instead, it supposed to be round and flattish, allowing transportation through membranes with tight gaps, which are common throughout the body’s circulatory system.

It is this crescent-shaped or sickle shaped character as well as a rigidity that is responsible for all of the problems that go along with sickle cell disease.

What Causes Sickle Cell Disease?

The cause of sickle cell disease is a gene mutation. Specifically, it is the gene that responsible for hemoglobin production.

Hemoglobin, an important protein found in red blood cells, attaches itself to oxygen molecules to help transport them around the body.

The mutation that causes sickle cell disease is a mutation involved in the production of the shape of red blood cells, resulting in the misshapen, rigid, sickle shaped design that is responsible for the problems that come with this difficult condition.

At the end of the day, the problem that is found with this condition is that of factors involved in causing a difficulty adjusting when the weather is cold, some occasional bouts of dizziness, and a lack of energy.

Diagnosis is actually extremely easy, and most cases of the disease are already detected by the time the baby is born. That said, to know for sure, a doctor will prescribe a blood test diagnosis that will determine precisely whether or not the patient carries the sickle cell abnormality and thus will suffer from effects associated with the disease.

A Solution and a Problem

If you understand more about sickle cell disease, it may not be too surprising to know that case density is greatest in areas where prevalence of malaria is to be found.

You see, the odd shape of red blood cells for individuals with sickle cell disease actually works to repel the spread of malaria throughout the body. Hence, over an even illusionary timeline, sickle cell disease has actually evolved as a defense in areas where malaria is particularly common in individuals are likely to be exposed to it.

In such places, having sickle cell disease actually decreases one’s chances of death, thereby increasing one’s chances of survival and eventual reproduction. This is why the disease has gained traction in certain areas of the world.

How Can CBD Help?

While there are no absolute treatments for sickle cell disease, cannabis and CBD have appeared to make a positive difference in both coping and managing the process that one must endure as a sufferer of sickle cell anemia.

CBD works to aid in the functionality of the immune system as well is the nervous system, thus treating many of the symptoms that are most often experienced by those with this terrible disease.

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