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CBD Treatment Case: Huntington’s Disease



As the pool of research data on CBD as a treatment and therapy for various health issues continues to grow, it is important that we continue to update our documentation on the various conditions amenable to this new tool for doctors and patients alike.

Huntington’s disease is an interesting case study. We are dealing here with an uncommon congenital disorder that results in a progressive degeneration of cortical tissue. The disorder is marked by an expansion of the HTT gene – which codes for an important protein involved in the functioning of neurons and the brain.

Symptoms of Huntington’s disease begin to show up between the ages of 30 – 50. Over time, symptomology progresses to impact motor skills and overall brain functioning, leaving individuals unable to live independently.

Understanding Huntington’s Disease

according to the WHO, between 50 and 70 people are impacted by Huntington’s disease for every million people on the planet. Most cases begin during early middle age and are marked by a range of symptoms that tend to show up by impacting motor control, affect, and overall cognitive functionality.

As noted above, this is all brought about by an expanded expression of an important gene that controls a protein central to brain functioning.

More specifically, the root cause of Huntington’s disease is a repeat coding of a protein generating gene located on chromosome 4. Parents can pass on a latent version of this condition due to the fact that the sequence of nucleotides end up being repeated in sequence more expansively in their offspring, leading to a manifestation of the condition for their children.

This same situation would happen in the following generation, leading to an even more severe genetic defect in their grandchildren.

The diagnostic side of the equation for Huntington’s disease is normally the result of a process of comparative data aligning inputs from standard medical examinations as well as a review of family history.

Through an understanding of one’s genetic history, a doctor will be able to determine whether or not the condition has been passed on through an examination of sensory symptoms, motor symptoms, and psychiatric symptoms that all can be understood as markers of the presence or absence of Huntington’s disease.

Unfortunately, there is no cure for Huntington’s disease. Any medications and treatments involved are merely palliative and meant to help an individual cope with an inevitable decline. This is often heartbreaking and increases the likelihood of late stage diagnosis simply because individuals at risk genetically for this disorder often don’t want to know whether or not they actually have it.

CBD and Huntington’s Disease

One of the essential characteristics of Huntington’s disease is an excess of glutamate precursor proteins found in the neurons of an affected patient.

This leads to an excess of intracellular calcium. That, in turn, leads to excessive action potential in the neuron. These excesses instigate a process known as apoptosis – or natural cell death.

Research has emerged that suggests an enhancement of endocannabinoid system receptor activation by the presence of administered CBD oil. This can lead to a blockage preventing the excesses in intracellular calcium.

In other words, exogenous cannabinoid exposure may potentially be a key to cutting off the process by which cell death is instigated at the neuronal level in cases of Huntington’s disease.

While much research remains to be done, this is a very promising starting point for what may potentially turn out to be an important new tool in the toolbox for those battling this terrible disease.


CannTrust Holdings Inc (NYSE:CTST) Penetrates Into The United States After Investing $20 Million



CannTrust Holdings Inc (NYSE:CTST), a Canadian company that produces and sells medical and recreational marijuana has announced the expansion of its business into the United States.

The Canadian firm revealed that it signed a Letter of Intent through which it will start working with Elk Grove Farming Company, LLC to access more than 3,000 hemp production acres in California. The two companies struck a joint partnership that will allow CannTrust to secure a footing in the California market which is one of the biggest cannabis markets in the U.S.

“This agreement represents another bold move for CannTrust. Our U.S. operation is expected to deliver a significant increase in low-cost production capacity,” stated CannTrust CEO Peter Aceto.

CannTrust is financially ready to tap into the U.S market

The CannTrust CEO also noted that the company will take advantage of its experience in the formulation of standardized CBD products as part of its strategy to enter the U.S market. Mr. Aceto also revealed that his company’s successful equity offering provided enough financial muscle to fuel its ambitious expansion plans.

CannTrust aims to be among the leading and trusted suppliers of high-quality, standardized CBD formulations derived from hemp. The company believes that there will be an increasing demand for high-grade CBD formulations from international retailers. It therefore makes sense to invest in processes that will add value to the end product such as genetic studies and expert growing practices to achieve the highest safety and quality standards.

Elk Grove and CannTrust will each have 50% ownership in their joint operations. Elk Grove is an ideal partner for the endeavor because it has years of farming experience in a variety of products. Its focus includes products designed for crop protection, supply, and input. Its operations are distributed across California, which means that the groundwork has already been laid for the partnership. It will thus be easier for the CannTrust to penetrate into the California market.

Elk Grove executive Morgan Houchin stated that his company was excited about the partnership with CannTrust. He added that his firm’s experience in farming operations will be a great combination with CannTrust’s experience in creating class-leading formulations.

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Rocky Mountain High Brands Inc (OTCMKTS:RMHB) Strikes Broker Deal With Carlin Group



Lifestyle brand management firm Rocky Mountain High Brands Inc (OTCMKTS:RMHB) announced on Wednesday that it secured a broker deal with Carlin Group for its products in the retail space.

The broker agreement will allow Carlin to represent RMHB’s CBD-infused drinks through the HEMPd brand. It will also represent beverages infused with Hempseed extract under RMHB brands. The deal will also cover CBD-infused wellness products such as lotions, water-soluble solutions, capsules, gummies and tinctures as part of the HEMPd brand. Spirit Water will also be covered under the agreement.

The RMHB-Carlin broker deal covers multiple states. They include Missouri, Nebraska, Texas, South Dakota, North Dakota, Minnesota, Wisconsin, Illinois, Pennsylvania, Tennessee, Kentucky, Ohio, Indiana, and Michigan.

“We are very excited about the opportunity to have our entire product line represented by Carlin Group,” stated RMHB CEO Michael Welch.

The Carlin broker deal will boost RMHB’s exposure

Welch noted that the broker deal will strategically allow RMHB to leverage optimal exposure to mass marketers, grocery store chains, convenient stores, major retailers and other types of outlets. The company would not have managed to reach such a wide range of outlets cost-effectively without a broker deal.

The RMHB CEO also added that his company and Carlin will maintain a close collaboration so that they can facilitate retail availability of RMHB products. Welch also revealed that RMHB reviewed numerous other retail introduction options. This was before settling on Carlin which the company believes is the best-suited brand to rapidly get its products onto retail shelves.

Carlin Group’s Managing Director Albert Vergilio noted in a statement that his company was excited to host RMHB and the CBD-based products that are part of its HEMPd brand in Carlin’s new CBD division. He also added that it is part of investing in the future of CBD considering the fast-tracked popularity of CBD products, and the regulations that govern them.

Carlin’s sales team will undergo some training to get them acquainted with RMBH’s products. The sales team will then hold meetings with corporate customers as part of the retail rollout of the products. Sales that will be part of the broker deal are expected to kick off in Q3.

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Wildflower Brands Inc (OTCMKTS:WLDFF) Establishes Footprint Across The US With PO For Hemp CBD Products From Dillard’s Department Stores And Eyes Markets In Texas And Florida



Wildflower Brands Inc (OTCMKTS:WLDFF) has announced establishing a nationwide presence with a PO from Dillard’s Department store. The company has fulfilled the PO received from Dillard.

Hemp CBD products in 292 locations

Dillard’s department store will showcase the premium hemp CBD products of Wildflower in its 292 locations across the US. With its best practices and transparency, Wildflower is eyeing the key markets in Texas and Florida. The company will educate the customers in these regions about salable products. Wildflower has received subsequent orders from Dillard’s and is fulfilling the requirements.

Chief Executive Officer of Wildflower, William Maclean said the supply of CBD infused products to Dillard’s Department stores doubles the existing retail locations in the nation. The company aims to capitalize on its brand to become a household name. It will improve loyalty building because of the reputation and respect of Dillard’s as a retailer. Wildflower aims to provide health and wellness benefits of its CBD infused products to the customers in the US through Dillard’s.

Signs a deal with Highmark Interactive

Wildflower has signed a deal to use EQ – Brain Tracking, mobile software of Highmark Interactive, in the clinical research to study the functional neurological and cognitive effects of CBD. The company aims to get meaningful results and data that help to understand the functional and cognitive neurological properties of the cannabinoids.

William said the company would collect testimonials from the customers on its products that provide the health and wellness needs using plant-based solutions. The company will strive to improve the products, and the research helps it to reach that goal and growth with continued investments.

Acquires City Cannabis Corp

Wildflower has signed an LOI on April 3, 2019, to take over City Cannabis Corp. The company will issue its 60 million common shares for the takeover. The companies will complete the acquisition on receiving advice from corporate, tax, and securities law departments.

The cannabis retailer City Cannabis holds two licenses in the City of Vancouver to market cannabis. It is generating profits through operating dispensaries in Vancouver. The acquisition helps Wildflower to expand retail footprint using the expertise of City Cannabis.

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