Lexaria Bioscience Corp (OTCMKTS:LXRP) recently announced that the company has been successful at delivering edible nicotine into blood plasma. The nicotine was delivered in vivo study a few minutes after dosing. As per the report, DehydraTECH technology developed by Lexaria delivered the edible nicotine at regular intervals of 2,4,6,8 and 10-minute after dosing in the animal. The study showed greater absorption levels as compared to control formulation.
Key highlights of study
Speed is of significant importance for oral drug administration. Importantly, its contribution is profound in the non-inhalation nicotine delivery format. During its third-party laboratory test, the study primarily kept its focus on analyzing absorption of edible nicotine over a period of 60 minutes giving particular emphasis on the dosing after first 15 minutes. This particular study was a follow-up of the vivo study conducted by Lexaria conducted on April 17 this year. In this study, the company tried the absorption level in smaller animal population in the time span of six hours.
The study revealed 79% improvement in blood levels at their peak at 394 ng/mL when DehydraTECH technology of Lexaria was compared against 220 ng.mL dose with control.
Lexaria’s bioavailability results
Recently the company revealed its bioavailability results from its placebo-controlled, randomized, double-blind European clinical study. In this study, DehydraTECH powered proprietary TurboCBD fortified with cannabidiol (CBD) hemp oil capsule was evaluated. The study detected the speed and degree in which the blood absorbed CBD into the blood plasma. Simultaneously, the study also tracked down whether the capsule potentially enhanced cognitive and cardiovascular performance in 12 male volunteers in their prime health.
It should be noted that very few companies have managed to achieve this success in a placebo-controlled, randomized, and double-blinded, appropriately controlled clinical trial in human volunteers. Such evaluations are highly important as they can be used as clinical evidence during the regulatory CBD scrutiny carried out by the US Food and Drug Administration in future. Also, the study will help in improving the commercial viability of Lexaria’s product containing CBD. Lexaria’s DehydraTECH technology has been repeatedly successful in producing evidence during human studies. That is why the company will hopefully continue to use this technology for other trials in human studies in the future.
Trulieve Cannabis Corp (OTCMKTS: TCNNF) Reopens North Port Dispensary, Formerly Harves House of Cannabis
Trulieve Cannabis Corp (OTCMKTS: TCNNF) has announced the reopening of a North Port, Florida dispensary. This dispensary located in the Sarasota area is the 92nd Trulieve location in the state and was previously named Harvest House of Cannabis.
Trulieve reopens North Port dispensary.
When the North Port site reopens as Trulieve, it will greet Harvest patients with the same devoted personnel and high-quality service as when it closed for renovations and rebranding. Trulieve announced the completion of its purchase of Harvest Health and Recreation Inc. on October 1, with all Harvest dispensaries in Florida closed for rebranding to Trulieve. Throughout the month of October, the Company will continue to reopen Harvest sites across Florida.
The company is inviting the community to celebrate the reopening of its dispensary with all-day specials and swag giveaways. On launch day, all patients, from newcomers to long-time Trulieve patients, will be eligible for a 25% discount at the North Port facility.
Patients will find the largest assortment of CBD and THC products in Florida, including edibles, concentrates, smokable flowers, tinctures, vaporizers, topical creams, and more, in stores and online. Trulieve also provides home delivery throughout the state, as well as web-based ordering and in-store pickups.
Products available online and in-store
Trulieve’s whole product portfolio is available for online orders to aid patients with ordering, with in-store pickup or home delivery options available across the state depending on customer preference. In addition, Trulieve provides complimentary 30-minute virtual consultations with a Trulieve expert to assist with product, device, or doctor’s suggestion questions. Appointments are available on Trulieve’s website and open to all patients, even if they are new to medical cannabis or those searching for new therapeutic choices.
The company is keeping an eye on the COVID-19 situation and is committed to limiting the virus’s spread. Trulieve requires all staff, regardless of vaccination status, to put on masks in addition to following strict cleanliness and safety measures.
ILUS International Inc. (OTCMKTS: ILUS) Announces Award Of a $1 Million Contract For Phase 2 Burj 2020 Project
ILUS International Inc. (OTCMKTS: ILUS) has announced that BDC Fire which it acquired on April 12, 2021, which had received three contract awards estimated at $1.5 million, has now received a $1 million contract for phase 2 of the Burj 2020 Project.
BCD Fie receives another $1 million contract
BCD Fore had previously received a contract for fire systems installation for the Burj 2020 Tower in Dubai. The company started work on the project inQ3 2020, and the contract value for the phase is around $1 million.
The company is committed to completing the project and upcoming projects, and as a result, it is recruiting an additional 45 technicians and salespeople. Hiring more technicians puts the company in a position to apply for the lucrative A-level license for installation, supply, and maintenance of fire systems in industrial, residential, and oil fields.
ILUS Managing DirectorJohn-Paul Backwell said, “BCD Fire has achieved so much since we acquired it earlier this year and the award of this next phase of the Burj 2020 project is reward for the progress made by the ILUS and BCD teams. Obtaining the A-level license will rocket this acquisition to a whole new level. There has also been overwhelming interest from regional Fire Safety Training Companies in our new Virtual Reality Fire Extinguisher Training Courses which are being launched this month.”
FireBug and TVC received numerous purchase orders
CEO Nick Link stated, “ILUS just closed out its best quarter yet and we are looking forward to releasing an update on this in the next week or so once the team has finished consolidating the figures. FireBug and TVC have received several purchase orders during the 3rd quarter and they have been making excellent progress, but we have felt it best to provide updates on the more significant deals in the region of $1 million and upwards or noteworthy clients.”
Roche Holding Ltd (OTCMKTS: RHHBY) To Present New OCREVUS and ENSPRYNG Data at ECTRIMS 2021
Roche Holding Ltd (OTCMKTS: RHHBY) has announced that it will present new ENSPRYNG (satralizumab) and OCREVUS (ocrelizumab) data during the 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis.
Roche to present ENSPRYNG and OCREVUS data
The data comprises 38 abstracts showing new long-terms safety and efficacy data for ENSPRYNG and OCREVUS and the company’s ongoing efforts to assess COVID-19’s impact on people living with multiple sclerosis. More data will shore enhanced scientific understanding of NMOSD and MS in various patient populations, ensuring access to treatment.
Roche’s chief medical officer and global product development head Levi Garraway, said, “The longer-term efficacy and safety data for both OCREVUS and ENSPRYNG reinforce e the impact of these treatments- by significantly slowing disease progression in MS and by preventing debilitating relapses in NMOSD, respectively. We continue to see that early and ongoing treatment markedly improves outcomes, and we’ll continues to use scientific and real-world insights to improve our understanding and ways to support people living with these neurological disorders.”
Roche to present data from 27 MS studies
The company will present 27 multiple sclerosis studies that include data showing earlier OCREVUS treatment continues to influence disability progression for around eight years in individuals with primary progressive MS and up to 7.5 years in patients with relapsing MS in the third phase open able trials. In addition, the company will present an updated long-term safety analysis of all clinical studies in RMS and PPMS patients that will reinforce OCREVUS’ favorable risk-benefit profile.
Roche is focused on addressing health disparities, and the company is optimistic that inclusive research will enhance outcomes and derive insights that can address treatment barriers. The company will present a subgroup analysis of three studies, including CHORDS, ENSEMBLE PLUS, and SaROD in Hispanic, Latino, and African-American populations treated with OCREVUS infusion. Roche is committed to increasing understanding of NMOSD and enhancing care for people living with the condition.