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Parkinson’s Disease and CBD Treatments



As adoption of CBD as a therapeutic supplement has continued to increase exponentially over recent years, one of the more interesting cases of application for this substance has been by those suffering from Parkinson’s disease.

Understanding Parkinson’s

This is a neurodegenerative disorder with no known cause or cure. Over a million people are affected in the United States alone, most of them seeing an onset following their 60th birthday.

The symptomology associated with Parkinson’s disease includes difficulty walking, depression and anxiety, a sharp reduction in the efficiency and effectiveness of the motor control system of the body, as well as the well-known tremors.

Parkinson’s disease is ultimately about a dysfunction and ultimate breakdown of those neurons located in the brain responsible for producing dopamine. Significantly, dopamine is something like the cheese in the laboratory rat maze that is our brain. It is the reward for our inbuilt systems programmed by evolution to result in behaviors that are associated with our survival and reproduction.

However, one of the areas of the brain that relies upon dopamine as its principal neurotransmitter is the motor system. Researchers and scientists do not yet know why only the motor cortex appears to be impacted by the type of breakdown in dopamine production associated with Parkinson’s disease.

Generally speaking, the body’s motor system works as a coordinated machine. There are pushes and pulls in every strand and every movement. On every level, there are protagonists and antagonists associated with this process.

In other words, at all levels, it is about maintaining a proper ratio of pushes to pulls. However, Parkinson’s disease breaks down this ratio by reducing our control mechanisms.

CBD and Parkinson’s

As we have discussed, CBD has a tremendous amount of impact on the functioning of the brain as well as the rest of the body. The endocannabinoid system spreads throughout the body, regulating many different systems and processes.

Given the above description of how Parkinson’s disease works, one might not be surprised to find out that CBD has shown itself to be an effective therapy along several dimensions for those suffering from this terrible disease.

In its early stages, Parkinson’s wreaks havoc on the substantia nigra, the dopamine producing cells of the brain. This part of the brain can lose over half of its mass just during the early stages of Parkinson’s.

Plasticity and the Endocannabinoid System

However, the brain has a feature known as plasticity. Plasticity essentially boils down to the brain’s ability to redirect those elements that are responsible for various tasks and functions. This allows the brain to reassign responsibilities to areas capable of taking them on. So, as one area of the brain loses mass at a substantial level, other areas of the brain pick up extra responsibilities. The net result is not that much of a change in how the brain functions overall.

However, interestingly enough, CBD has an impact on the endocannabinoid system that augments the brain’s ability to take advantage of this instinctual proclivity toward plasticity.

Delayed Progression and Mood Enhancement

In its middle stages, the course of the disease path for those stricken by Parkinson’s accelerates, leading to an actual darkening of the color of surrounding brain tissue.

As the disease progresses further, the build-up of this plaque tissue becomes toxic, and severely exaggerates the symptomology of the disease.

However, CBD, CBC, and CBG, the principal antioxidant cannabinoids, have been shown to be able to impact the overall brain system as this plaque builds so as to slow the progression of this disease.

In addition, the depression and anxiety that often accompanies this stage of Parkinson’s can be aided by therapeutic application of CBD as well.

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CannTrust Holdings Inc (NYSE:CTST) Penetrates Into The United States After Investing $20 Million



CannTrust Holdings Inc (NYSE:CTST), a Canadian company that produces and sells medical and recreational marijuana has announced the expansion of its business into the United States.

The Canadian firm revealed that it signed a Letter of Intent through which it will start working with Elk Grove Farming Company, LLC to access more than 3,000 hemp production acres in California. The two companies struck a joint partnership that will allow CannTrust to secure a footing in the California market which is one of the biggest cannabis markets in the U.S.

“This agreement represents another bold move for CannTrust. Our U.S. operation is expected to deliver a significant increase in low-cost production capacity,” stated CannTrust CEO Peter Aceto.

CannTrust is financially ready to tap into the U.S market

The CannTrust CEO also noted that the company will take advantage of its experience in the formulation of standardized CBD products as part of its strategy to enter the U.S market. Mr. Aceto also revealed that his company’s successful equity offering provided enough financial muscle to fuel its ambitious expansion plans.

CannTrust aims to be among the leading and trusted suppliers of high-quality, standardized CBD formulations derived from hemp. The company believes that there will be an increasing demand for high-grade CBD formulations from international retailers. It therefore makes sense to invest in processes that will add value to the end product such as genetic studies and expert growing practices to achieve the highest safety and quality standards.

Elk Grove and CannTrust will each have 50% ownership in their joint operations. Elk Grove is an ideal partner for the endeavor because it has years of farming experience in a variety of products. Its focus includes products designed for crop protection, supply, and input. Its operations are distributed across California, which means that the groundwork has already been laid for the partnership. It will thus be easier for the CannTrust to penetrate into the California market.

Elk Grove executive Morgan Houchin stated that his company was excited about the partnership with CannTrust. He added that his firm’s experience in farming operations will be a great combination with CannTrust’s experience in creating class-leading formulations.

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Rocky Mountain High Brands Inc (OTCMKTS:RMHB) Strikes Broker Deal With Carlin Group



Lifestyle brand management firm Rocky Mountain High Brands Inc (OTCMKTS:RMHB) announced on Wednesday that it secured a broker deal with Carlin Group for its products in the retail space.

The broker agreement will allow Carlin to represent RMHB’s CBD-infused drinks through the HEMPd brand. It will also represent beverages infused with Hempseed extract under RMHB brands. The deal will also cover CBD-infused wellness products such as lotions, water-soluble solutions, capsules, gummies and tinctures as part of the HEMPd brand. Spirit Water will also be covered under the agreement.

The RMHB-Carlin broker deal covers multiple states. They include Missouri, Nebraska, Texas, South Dakota, North Dakota, Minnesota, Wisconsin, Illinois, Pennsylvania, Tennessee, Kentucky, Ohio, Indiana, and Michigan.

“We are very excited about the opportunity to have our entire product line represented by Carlin Group,” stated RMHB CEO Michael Welch.

The Carlin broker deal will boost RMHB’s exposure

Welch noted that the broker deal will strategically allow RMHB to leverage optimal exposure to mass marketers, grocery store chains, convenient stores, major retailers and other types of outlets. The company would not have managed to reach such a wide range of outlets cost-effectively without a broker deal.

The RMHB CEO also added that his company and Carlin will maintain a close collaboration so that they can facilitate retail availability of RMHB products. Welch also revealed that RMHB reviewed numerous other retail introduction options. This was before settling on Carlin which the company believes is the best-suited brand to rapidly get its products onto retail shelves.

Carlin Group’s Managing Director Albert Vergilio noted in a statement that his company was excited to host RMHB and the CBD-based products that are part of its HEMPd brand in Carlin’s new CBD division. He also added that it is part of investing in the future of CBD considering the fast-tracked popularity of CBD products, and the regulations that govern them.

Carlin’s sales team will undergo some training to get them acquainted with RMBH’s products. The sales team will then hold meetings with corporate customers as part of the retail rollout of the products. Sales that will be part of the broker deal are expected to kick off in Q3.

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Wildflower Brands Inc (OTCMKTS:WLDFF) Establishes Footprint Across The US With PO For Hemp CBD Products From Dillard’s Department Stores And Eyes Markets In Texas And Florida



Wildflower Brands Inc (OTCMKTS:WLDFF) has announced establishing a nationwide presence with a PO from Dillard’s Department store. The company has fulfilled the PO received from Dillard.

Hemp CBD products in 292 locations

Dillard’s department store will showcase the premium hemp CBD products of Wildflower in its 292 locations across the US. With its best practices and transparency, Wildflower is eyeing the key markets in Texas and Florida. The company will educate the customers in these regions about salable products. Wildflower has received subsequent orders from Dillard’s and is fulfilling the requirements.

Chief Executive Officer of Wildflower, William Maclean said the supply of CBD infused products to Dillard’s Department stores doubles the existing retail locations in the nation. The company aims to capitalize on its brand to become a household name. It will improve loyalty building because of the reputation and respect of Dillard’s as a retailer. Wildflower aims to provide health and wellness benefits of its CBD infused products to the customers in the US through Dillard’s.

Signs a deal with Highmark Interactive

Wildflower has signed a deal to use EQ – Brain Tracking, mobile software of Highmark Interactive, in the clinical research to study the functional neurological and cognitive effects of CBD. The company aims to get meaningful results and data that help to understand the functional and cognitive neurological properties of the cannabinoids.

William said the company would collect testimonials from the customers on its products that provide the health and wellness needs using plant-based solutions. The company will strive to improve the products, and the research helps it to reach that goal and growth with continued investments.

Acquires City Cannabis Corp

Wildflower has signed an LOI on April 3, 2019, to take over City Cannabis Corp. The company will issue its 60 million common shares for the takeover. The companies will complete the acquisition on receiving advice from corporate, tax, and securities law departments.

The cannabis retailer City Cannabis holds two licenses in the City of Vancouver to market cannabis. It is generating profits through operating dispensaries in Vancouver. The acquisition helps Wildflower to expand retail footprint using the expertise of City Cannabis.

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