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Sickle Cell Anemia and CBD



Few people realize that sickle cell anemia is actually one of the most common congenital disorders.

In fact, we don’t even know how many people are affected by SCA worldwide, but the number is expected to be well into the millions. At particular risk are those in sub-Saharan Africa, Southwest Asia, India, and Mediterranean countries.

Understanding Sickle Cell Anemia

Sickle cell anemia is a form of the sickle cell disease, as its name likely suggests. The disease is characterized by a crescent shape for red blood cells. As most readers probably know, red blood cells are the cells in charge of transportation of oxygen around the body.

A healthy, normal red blood cell is generally flattish and round in profile. This design allows them the flexibility to fit through tight gaps as they race around the circulatory system.

For those suffering from sickle cell disease, such cells are sickle shaped as well as highly rigid in a manner that can cause many issues.


It is actually mutation of a gene in charge of production of hemoglobin’s that is at the root cause of sickle cell anemia.

Hemoglobin is a protein in our red blood cells that binds to oxygen for transportation. The mutation involved in sickle cell disease, as noted above, produces sickle shaped, rigid, and ineffective red blood cells.

That’s why those suffering from sickle cell anemia often report dizziness, difficulty adjusting to colder temperatures, and lethargy.

For those dealing with sickle cell anemia, the defective hemoglobin, and the resultant form error and rigidity of the red blood cells, reduces the effectiveness of the cell in the transportation of oxygen. We know that much. However, there is an even bigger problem: this same condition can lead to a blockage in the capillaries as the cells pileup on one another and don’t properly fit through the tight spaces characterizing the distal regions of the circulatory system.

It’s this secondary set of symptomology that really causes the danger for sickle cell disease.

In terms of identifying the condition, because it comes down to genes, many cases are known before birth. However, to establish it for certain, doctors will simply use a blood test. Interestingly, several European countries advise couples to have an abortion when a fetus in utero is known to have this disease.

Darwin’s Revenge

Eight out of every ten cases of sickle cell anemia occur in sub-Saharan Africa. The reason is an evolutionary one: the sickle shape of the cells actually repels malaria, and malaria is most common in sub-Saharan Africa.

Hence, over great swaths of time, individuals living in an area where a disease like malaria is highly prevalent will have a better chance of surviving and reproducing if there circulatory system is seeded with cells and resistant to the disease.

As for treatment, all we can really do at this point is seek to relieve pain through the use of opioids and morphine. However, obviously these have side effects.

Blood transfusions and bone marrow transplants are also common, but they tend to have their own list of risks and associated side effects.

At this point, there is no cure for sickle cell anemia. Ideal management of the disease will generally lead to a lifespan that is only about three quarters of a normal human lifespan in the developed world.

CBD and Sickle Cell Anemia

As noted above, there are no definite treatments for the disease, but many people have used cannabis and CBD to attempt to cope better and manage the process of dealing with sickle cell anemia.

Research has shown that CBD, in particular, normalizes immune system and nervous system disruptions, which can reduce the impact of the symptoms associated with sickle cell anemia

One recent study showed that mice affected by something similar to sickle cell anemia actually experienced less pain and less inflammation once cannabinoids receptors were properly activated.

For scientists, the conclusions from this study have powerfully shifted our understanding of this disease.

At this point, while CBD is definitely not a cure all for the sickle cell disease and sickle cell anemia, it may become more widely used in such cases and has already shown to be a valuable tool for those suffering from this terrible disease.

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Healing Properties CBD and Addison’s Disease



Primary adrenal insufficiency, also known as Addison’s disease, is a very rare condition that impacts the adrenal cortex, resulting in a number of very difficult symptoms, including a lack of appetite, lethargy, possible adrenal crisis, loss of weight, and erratic mood.

One of the symptoms noted above – adrenal crisis – is a particularly acute experience that should be treated as a medical emergency. During that adrenal crisis, one may experience a dramatic loss of blood pressure accompanied by dizziness, lower body pain, and fainting spells.

Such an attack can result in death.

Coming to Grips with Addison’s Disease

The adrenal cortex is a rare instance of the word cortex being applied to something that is outside of the brain. In fact, the adrenal cortex is found on the top of the kidneys, and is made of a couple of different glands.

This is part of the HPA, which is an important axis of connected components that regulate many different functions in the body.

One element of this system is known as the endocrine system, which is in charge of various molecular signals in the body, such as hormones. The regulation of this system is critical in a number of different processes that sit at the very core of our physiological functionality.

On the other hand, the adrenal system is in charge of things like our ability to deal with sudden danger – commonly known as the fight or flight system. This is how we respond to highly stressful and highly dangerous situations encountered unexpectedly during daily life. Much of this is dealt with by the pituitary gland, which produces important chemical components that instinctively energize responses in the body.

For those suffering from Addison’s disease, we see it atrophying of this core system. This interrupts the processes that allow us to behave in a manner that our bodies were designed.

Without this properly functioning system we can end up lacking important responses in certain situations while having those responses happen to us in inappropriate situations. But we can also have a number of other symptoms such as those described above.

The role of CBD In Addison’s Disease

It’s certainly true that Addison’s disease is relatively uncommon. However, CBD is an excellent resource for those suffering from this terrible condition.

In our other pieces, we have previously described the importance of the endocannabinoid system and how it is tied throughout the body’s important systems.

Well, as you might have guessed, the endocannabinoid system is also an important part in dealing with Addison’s disease. Because this is such a critical and interconnected system throughout the body, you’ll find that it has a very complex relationships with many different sources of discomfort, malady, and disease. The case of Addison’s disease is no different.

CBD can be an important component in treating and or preventing a case of Addison’s disease because it isn’t impactful element in the functionality of the endocannabinoid system, as we have discussed in our prior pieces. In fact, much anecdotal evidence exists alongside some genuine research by the medical and scientific community to support these contentions.

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The Effects of CBD and Glaucoma



facts about CBD and Glaucoma

As we discussed the variety of different health conditions that appear to be treatable or preventable through the use of CBD, we must admit to the existence of a spectrum of efficacy. In other words while it appears to have an enormous range of application, there are certain things that it works even better for than others.

One of the best of the bunch is glaucoma.

As the reader is likely aware, glaucoma is a defect with implications for severe damage to an individual’s optic nerve, and thus a failure in the proper functionality of the eye.

Coming to Terms with Glaucoma

While we don’t understand exactly how it’s cause, the most relevant source of serious long-term damage to the optic nerve in cases of glaucoma appears to be hypertension on an intraocular level. In other words,, comes from too much pressure inside of the eye because of too much fluid in between the iris and cornea.

How prevalent is glaucoma? About 2 million suffer from it just in the US. Most of them are around 50 years of age or older by the time we actually see signs of the glaucoma.

The early stage symptomology is relatively inconspicuous. The first thing you deal with in a case of glaucoma’s difficulty seeing out to your periphery – otherwise known as a loss of peripheral vision. If this happens to you, unfortunately I have some bad news: glaucoma is already irreversible at this stage.

This is when we know that there’s already too much pressure directly in the eye and damage is already been done to the optic nerve.

While we don’t fully understand exactly why or how this happens from the outset, the consequences are undeniable.

Here’s how it breaks down: the eye produces something called aqueous humor. No, that’s not a comedy club for fish. It’s actually a fluid it’s meant to sit between the iris and cornea of the eye. But when there’s too much of it, it results in pressure that can damage the optic nerve. It’s also important to understand that this is a very sensitive system.

The optic nerve is actually a highly delicate grouping of nerve tissue and it’s easily damaged. It is a highly delicate instrument. Any alteration leads to irreversible issues with vision.

Can CBD Help?

As we have described, glaucoma is the result of a failure to regulate some delicate balance of some kind of substance somewhere in the body – in this case, the aqueous humor in the eye. What we want to highlight here is that this is a regulatory issue.

While CBD is still on the frontier of its important research development, one thing we have learned for certain at this point is this: CBD is great at regulatory problems.

Why? Because CBD impacts the endocannabinoid system, and the endocannabinoid system is intimately tied into most of the body’s major regulatory systems.

That’s why it’s so good at helping with immune system issues, inflammation issues, pain management, and hormonal balance. These are all important regulatory functions in the body, and ones that the endocannabinoid system is intimately integrated within.

As such, anecdotal and formal research has shown CBD could be a highly valuable tool in the battle against glaucoma. While more research needs to be conducted, we already know that it’s effective, and we already have a pretty good idea why.

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Treatment Option for CBD and Sickle Cell Anemia



Did you know that scientists aren’t even sure how many people are affected by sickle cell anemia in the world right now? Most people don’t realize that one of the most frequently identified hereditary conditions is in fact sickle cell anemia.

While we don’t know exactly how many people suffer from this difficult condition, we do know that it’s at least millions. Those living in Southwest Asia, the Mediterranean countries, Africa, and India are most at risk.

Coming to Grips with Sickle Cell Anemia

Sickle cell anemia is a common version of the sickle cell disease, as you might guess. The most important and peculiar characteristic that defines this disease is a crescent shape found in red blood cells.

A red blood cell isn’t supposed to be crescent-shaped. Instead, it supposed to be round and flattish, allowing transportation through membranes with tight gaps, which are common throughout the body’s circulatory system.

It is this crescent-shaped or sickle shaped character as well as a rigidity that is responsible for all of the problems that go along with sickle cell disease.

What Causes Sickle Cell Disease?

The cause of sickle cell disease is a gene mutation. Specifically, it is the gene that responsible for hemoglobin production.

Hemoglobin, an important protein found in red blood cells, attaches itself to oxygen molecules to help transport them around the body.

The mutation that causes sickle cell disease is a mutation involved in the production of the shape of red blood cells, resulting in the misshapen, rigid, sickle shaped design that is responsible for the problems that come with this difficult condition.

At the end of the day, the problem that is found with this condition is that of factors involved in causing a difficulty adjusting when the weather is cold, some occasional bouts of dizziness, and a lack of energy.

Diagnosis is actually extremely easy, and most cases of the disease are already detected by the time the baby is born. That said, to know for sure, a doctor will prescribe a blood test diagnosis that will determine precisely whether or not the patient carries the sickle cell abnormality and thus will suffer from effects associated with the disease.

A Solution and a Problem

If you understand more about sickle cell disease, it may not be too surprising to know that case density is greatest in areas where prevalence of malaria is to be found.

You see, the odd shape of red blood cells for individuals with sickle cell disease actually works to repel the spread of malaria throughout the body. Hence, over an even illusionary timeline, sickle cell disease has actually evolved as a defense in areas where malaria is particularly common in individuals are likely to be exposed to it.

In such places, having sickle cell disease actually decreases one’s chances of death, thereby increasing one’s chances of survival and eventual reproduction. This is why the disease has gained traction in certain areas of the world.

How Can CBD Help?

While there are no absolute treatments for sickle cell disease, cannabis and CBD have appeared to make a positive difference in both coping and managing the process that one must endure as a sufferer of sickle cell anemia.

CBD works to aid in the functionality of the immune system as well is the nervous system, thus treating many of the symptoms that are most often experienced by those with this terrible disease.

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